The couple, who have a three-year-old son, took steps to keep the details of the split private, requesting that documents be sealed by the court.
Brin, 48, has a fortune of $94 billion, according to the Bloomberg Billionaires Index, derived largely from his holdings in Google
Brin's earlier marriage to 23andMe co-founder Anne Wojcicki ended in divorce in 2015.
His most recent split comes a year after Bill Gates and Melinda French Gates announced the dissolution of their marriage and about three years after Jeff Bezos and MacKenzie Scott divorced.